New study from Finland evaluates utility of NEW ESPGHAN criteria for celiac disease.  Published in the Journal of Pediatric Gastroenterology and Nutrition this Month.

My take home is that if you have  low or borderline TTG, caution should be used in diagnosing celiac disease.  With a TTG >100 (depending on the scale), and DQ2/DQ8 positive, there is a high likelihood of having celiac disease. The ESPGHAN guidelines suggest if TTG >100 and genetics positive, a biopsy may not be necessary.  Not sure if this data is as applicable for children at this point where TTG not as sensitive. Keep in mind the high rate of DQ2 and DQ8 positivity in the general population…..Further prospective studies will be necessary before this is adopted as the new “gold standard” in the United States.


J Pediatr Gastroenterol Nutr. 2012 Mar;54(3):387-91.

Utility of the New ESPGHAN Criteria for the Diagnosis of Celiac Disease in At-risk Groups.


*Pediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere †Department of Medical Genetics and Research Program for Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki ‡Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.



: Demonstration of small-bowel mucosal damage has been the basis of celiac disease diagnosis, but the diagnostic approach is undergoing changes. The European Society for Pediatric Gastroenterology, Hepatology, and Nutrition recently stated that in a subgroup of children, high positive transglutaminase 2 antibody (TG2ab) values may be sufficient for the diagnosis. The utility of these new criteria was evaluated by applying the human red blood cell TG2 antibody test (RBC-TG2ab) to a large cohort of children and adults belonging to at-risk groups.


: RBC-TG2ab and endomysial antibodies (EmA) were measured in 3031 family members or other relatives of patients with celiacdisease. The RBC-TG2ab values were classified as weak (20-29 U), moderate (30-99 U), and strong (≥100 U) positive. Seropositive subjects were further tested by human recombinant TG2ab (Hr-TG2ab) and for the presence of celiac disease-associated human leukocyte antigen-DQ alleles. Gastroscopy was recommended for all with positive RBC-TG2ab, EmA, or Hr-TG2ab, or weak positive RBC-TG2ab and symptoms.


: Strong positive RBC-TG2ab has good correlation with EmA and Hr-TG2ab and positivity of DQ2/8, and the diagnosis was established in 94% of both children and adults. In contrast, moderately positive (≥30 U) RBC-TG2ab showed poor correlation with the other tests, and celiacdisease was diagnosed in 69% of children and 86% of adults. Most participants with weak positive RBC-TG2ab were negative for EmA and Hr-TG2ab.


: In accordance with the new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition criteria, strong positive RBC-TG2ab showed good accuracy and excellent correlation with the other antibodies and celiac-type human leukocyte antigen. In contrast, low or moderately positive RBC-TG2ab values were of unsatisfactory prognostic value for a subsequent diagnosis.


Top GF Restaurants in NYC

On March 29, 2012, in For Foodies, by celiacuniverse

Risotteria tops NYC GF list. Check out
Coming soon, my national list of top GF restaurants….

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